9 Signs and Symptoms of Vitamin B6 Deficiency

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Vitamin B6 helps your body metabolize carbs, fat, and protein from diet. It is needed to make red blood cells and neurotransmitters.  

Vitamin B6 deficiency can cause skin rashes over months or years.A red, itchy rash called seborrheic dermatitis can result from vitamin B6 deficiency. Rashes are flaky, greasy, and cause puffy or white spots on the scalp, neck, face, and upper chest.  

Skin rashes 

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Deficient vitamin B6 can cause scaly, chapped lips and cracked mouth corners. Talking or eating can be painful with this sensation. Riboflavin, folate, iron, and other vitamin deficits can also produce cracked and dry lips.   

Cracked and dry lips 

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Low vitamin B6 levels can induce glossitis, a swollen, smooth, painful, red, or inflamed tongue.Glossitis is caused by tongue papillae loss. Glossitis affects eating, swallowing, and speaking.  

Sore and glossy tongue 

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Prevention of infections, inflammation, and disease requires a strong immune system. The following can damage the immune system without enough vitamin B6.  

Weak immune system 

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Deficient vitamin B6 can cause peripheral neuropathy. Peripheral neuropathy causes burning, shooting, and tingling in the arms, legs, hands, and feet. Possible symptoms include  

Tingling in the hands or feet 

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Anemia and vitamin B6 deficiency cause fatigue and decreased energy. Hemoglobin, which transports oxygen, is made by vitamin B6. Anemia, caused by insufficient hemoglobin, can cause weariness.  

Low energy 

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GABA, an inhibitory neurotransmitter that calms agitated neurons and prevents seizures, is produced by vitamin B6. Muscle spasms, uncontrollable shaking, and loss of consciousness can result from seizures.  


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Deficits in vitamin B6 can cause age-related cognitive decline and memory loss. Vitamin B6 deficiency increases homocysteine levels, which are linked to stroke, Alzheimer's, and other nervous system disorders.   

Brain fog 

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Vitamin B6 produces neurotransmitters like serotonin and GABA, which alleviate anxiety, depression, and mood swings.  

Mood changes 

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Vitamin B6-rich meals help reverse B6 deficiency.  Supplements can prevent B6 deficiency. The safe daily vitamin B6 dose is under 100 mg.  


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